2216 is newer SMD LED chips,it is higher brightness and smaller size than the 3528, with the size of 2216 SMD LED is about 2.2*1.6mm and the heat dissipation pad structure on the back.
for the smaller size ,the application can be small pitch,for the 2216 flexible led strip can be P3.33 (led to led center distance is 3.33mm),that is 300led/m led strip,it has no dot spot when installed with the diffuse cover inside the aluminum profile or the led tube.